“A
biomarker is a substance used as an indicator of a biologic state. It is a
characteristic that is objectively measured and evaluated as an indicator of
normal biologic processes, pathogenic processes, or pharmacologic responses to
a therapeutic intervention.”
Cardiac
biomarkers are substances which are released by cardiac muscle cells when the
cells are damaged or stressed, such as myocardial infarction.
Biomarkers
express cardiac specificity:
Troponin I and T
CK-MB
CK (CPK)
LMyoglobinD (LDH)
Others
Cardiac biomarkers play important
roles in: early diagnosis of acute myocardial infarction, acute coronary syndrome;
evaluation of myocardial damages; prediction of prognosis in some cardiac disease
patients.
Among all these cardiac
biomarkers, Troponin I and T are currently recognized as the most sensitive ones
which have more than 20 year’s history.
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