Myocardial infarction is defined pathological perspective as myocardial cell death (necrosis) due to prolonged
ischemia. Infarcts are classified temporally according to the pathologic
appearance as follows: acute (6 h to 7 days); healing (7 to 28 days), healed
(29 days or more).
The diagnosis of acute myocardial
infarction (AMI) is defined by the World Health Organization as the
presence of at least two of three criteria: typical symptoms (i.e., chest
pain), electrocardiogram (ECG) abnormalities and increased cardiac enzyme
levels.
Cardiac troponin I is a sensitive cardiac biomarker which generalized be
used in hospitals especially emergency department in patients with chest pain
or ECG has ST elevation for the early detection and diagnosis of myocardial
infarction.
From empirical studies obtained and selected, the high sensitive
troponin I assay has the highest diagnostic accuracy. With the use of the
sensitive troponin assay, the early detection of myocardial is infarction
increased by 29%.
When I think of necrosis I always think of massive death of host tissue cells, therefore i wonder if necrosis is possible, what is the mortality of the Cardiac Troponin I and Acute Myocardial Infarction. I also wonder does a patient fully recover from the necrosis after being healed?
ReplyDeleteThis is a very great topic! So many individuals have died due to myocardial infarction. Through the early detection of Acute Myocardial Infarction, numerous of lives can be saved. I didn't know cardiac troponins are released into circulation in response to myocardial necrosis. With the accuracy being high,cardiac troponin makes for a great biomarker to be used internationally.
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